UMAP
Cluster (0.1)

Sample

No integration needed.
Markers
resolution : 0.1
total 5 clusters
Marker genes dotplot

Cluster annotation
cluster0 : Antigen presenting cell + macrophage
cluster1 : Neutrophil
cluster2 : T cell
cluster3 : Macrophage
cluster4 : Antigen presenting cell
Cluster2 : clonotype-associated cluster
Marker genes Dotplot Extended (vertical)
Genes were selected by Sung.

Marker genes Dotplot Extended (horizontal)

Heatmap

DEGs between ADU/CTL
Significant genes cutoff
FDR=0.05
fold change=1.2
GSEA of DEGs
Hallmark pathway enrichment
NES Plot Cluster3 : Macrophage

NES Plot Cluster0

NES Plot Cluster1

NES Plot Cluster2

NES Plot Cluster4

Comparison of Interferon genes
Interferon-related genes
Isg15, Isg20, Ifitm3, Ifit1, Ifit3, Ifngr1, Irf7, Irf5, Irf8,
Irf3
Cluster 3

Cluster 0

Cluster 1

Cluster 2

Volcanoplot
Cluster 3

Cluster 0

Cluster 1

Cluster 2

Cluster 4
